A peptide-based technology called CURODONT REPAIR offers an alternative to traditional drilling and filling for early-stage tooth decay. Instead of removing damaged enamel, the treatment uses self-assembling peptides to guide the tooth to rebuild itself through a biomimetic regenerative process.

How peptide-based enamel regeneration works

The treatment applies a liquid peptide solution to the tooth surface. In early carious lesions, the peptide diffuses into the demineralised, porous subsurface of the enamel. Once inside the acidic environment of the lesion, the peptide self-assembles into a three-dimensional matrix that mimics the natural enamel structure. This scaffold arrests the progression of the lesion and attracts calcium and phosphate ions from saliva, forming new hydroxyapatite crystals. The regeneration occurs throughout the depth of the lesion, not just at the surface, restoring mineral density and structural integrity.

Clinical advantages and adoption

The procedure requires no drilling or local anaesthetic and can be delivered by dentists, dental hygienists, and dental therapists. CURODONT REPAIR is the first commercially available peptide-based regenerative treatment for early-stage caries. The technology has been developed over more than two decades and supported by over 250 scientific publications, including peer-reviewed studies and real-world evidence demonstrating a success rate above 90 percent. Globally, the treatment has been used on more than 2.5 million teeth. Unlike traditional preventive approaches that work only at the surface, this peptide technology addresses subsurface mineral loss and enables earlier clinical intervention before restorative treatment becomes necessary.