A systematic review from the University of Sharjah, published in the Journal of Herbal Medicine, found that high-concentration garlic extract mouthwash produced antimicrobial results comparable to chlorhexidine across five randomised controlled trials and clinical studies. Researchers identified 389 articles from six databases and included only those meeting strict criteria, leaving a small but consistent body of evidence. Some studies favoured chlorhexidine for plaque and salivary pH control, while others found garlic extract more effective at specific concentrations. Garlic's active compound, allicin, appears to account for its antibacterial and antifungal properties, with the review also noting potential applications in denture stomatitis, dentinal tubule disinfection, and intracanal medication. Reported side effects include a burning sensation and unpleasant odour, which may reduce patient acceptance compared to chlorhexidine. The review also noted that garlic mouthwash may offer longer-lasting residual antimicrobial activity. The authors call for larger trials with longer follow-up periods before garlic extract can be recommended as a routine clinical alternative. For dental professionals, the findings suggest garlic-based rinses could be a candidate for patients who cannot tolerate chlorhexidine, though the current evidence base remains too small to change prescribing practice.